My family started folloiwing Dr. Hyman's book about 6 months ago. First, I will report that my 79 year old mother finally figured out that 5- MTFH was her critical factor (she is using other supplements recommended in the book as well.)  She recently related to me, "I have never felt good, my entire life.....but now I have so much energy and feel well!"  

Me, I'm still struggling with the process.  I have been on an elimination diet for 5 months which helped with some of my digestive discomfort.  Fatigue and food allergies are still a problem. Basically, the only things I can eat are meats, eggs, vegetables, and healthy fats.  No grain, nuts, dairy, vinegar, sugar, fruit, beans, etc.  

I need to find a Functional Medicine practitioner in central or northern California who can help sort out the multiple supplements that I "should" be taking.  I haven't tried 5-MTFH yet because there are so many other supplements that need to be in order as well.

I did get a diagnosis of cyst forms of entamoeba coli, which I am currently being treated for with Yotoxin (10 days).  Don't yet know how much this will help my digestion, multiple food allergies, and fatigue.  My doctor seems to treat me as a cookie cutter, not an individual.  Unlike Dr. Hyman, he applies his same strategies to all.